AB1323 THE MYSTERY OF FAMILIAL MEDITERRANEAN FEVER: IS THERE ANY FACTOR TRIGGERING THE ATTACKS?

Background Familial Mediterranean Fever (FMF) is an autoinflammatory disease characterized by recurrent episodes of fever and serositis. Although it known that the attack frequency differs among patients carrying different mutant genotypes [1], whether physical environmental factors play a role in triggering attacks or they have influence on timing remains to be elucidated. Objectives We aimed identify conditions causing flare-ups FMF course investigate if there significant difference between distinct mutations, regarding distribution mentioned. Methods Two hundred were randomly selected individuals who routinely followed-up with diagnosis our centre. Individuals only variant unknown significance polymorphism such as R202Q, according Infevers database, excluded order gather cohort consisting definite FMF. An inquiry was made based upon determined themselves. The classified into subgroups their sex mutation genotype. Since M694V responsible for pronounced [2], we sorted status allele. Group A included homozygously. B at least one allele whereas C consisted non-M694V carriers. Chi-square test performed assess trigger terms establishing its significance. Results Detailed shown Table 1. 144 out 200 described culprit condition. Patients usually stated more than factor, however some reported one. most-reported are summarized following: 76 emotional stress (38%), 60 menstruation (30%), 40 cold exposure (20%), 34 fatigue (17%), 13 seasonal changes (6.5%). A, B, non-significant (p=0.88). subgroups. Total(%) Reported factor (%) Mens- truation(%) Emotionalstress(%) Cold exposure(%) Fatigue(%) Seasonalchanges(%) Others(%) Female 123 97 (78.8) (48.8) 47 (38.2) 24 (19.5) 19 (15.4) 7 (5.7) 6 (4.9) Male 77 (61) - 29 (37.7) 16 (20.8) 15 (7.8) (9.1) 61 44 (72.1) 14 (23) (39.3) (21.3) 12 (19.7) 4 (6.6) (9.8) 165 120 (72.7) 49 (29.7) 66 (40) (20.6) (17.6) (7.9) 11 35 (68.6) (31.4) 10 (28.6) (17.1) 5 (14.3) 0 1 (2.8) A: homozygous patients, B: allele, C: carriers Conclusion concluded did not vary genotypes. most participants, should bear mind influences chronic diseases negatively. also observed overtly triggers attack. Additionally, considered notable factor. It still unclear what 28% mystery. References [1]Grossman C, Kassel Y, Livneh Ben-Zvi I. phenotype MEFV mutation. Eur J Med Genet. 2019 Jun;62(6):103532. doi: 10.1016/j.ejmg.2018.08.013. [2]Egeli BH, Ugurlu S. Fever: Clinical State Of Art. QJM. 2020 Oct 20:hcaa291. 10.1093/qjmed/hcaa291. Disclosure Interests None declared